深圳市瑞普逊干细胞再生医学研究院

Shenzhen Ruipuxun Academy  for Stem Cell & Regenerative Medicine

赵严 博士

 个人简介:

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

     

博士主任医师博士生导师

5年发表国内外学术论文14

 

现担任

1)中华医学会胰腺学组:全国委员;

2)中华医学会消化病学分会第一届青委会协作组:全国委员;

3)上海申康医院发展中心少数民族联合会:理事;

4)上海市医学会胰腺学组:委员;

5)上海市医学会幽门螺杆菌学组:委员;

6) 上海市抗癌协会内镜学组:委员;

7)上海市抗癌协会学组:委员。擅长胰腺相关疾病诊治及其他消化内科急危重疾病的诊治,对于消化内镜可以熟练开展消化道早癌的诊治,EMRESD等技术,消化道狭窄的内镜支架置入术,内镜下止血,超声内镜,胶囊内镜,小肠镜及十二指肠镜的操作。

 

已经及现阶段主持的科研项目如下:

1)国家自然科学基金青年项目,主持,FFA-FABP1-PPARα轴在高脂血症性胰腺炎动物模型中促进炎症重症化演变及调控的分子机制研究,812003202013.01.1-2015.12.31

2)上海市卫生局青年项目,主持,CD9表达与胰腺癌细胞侵袭转移的研究,201143152012.01.01-2014.12.31

3)上海市第十人民医院 院内优秀学术骨干项目,主持,FABPs在高脂血症性胰腺炎重症化演变及调控的分子机制研究 ,2013.012014.12

4)上海市第十人民医院 院内后备博导项目,主持,CD9表达在胰腺癌发病机制中的研究,2014.01-2015.12

5)国家自然科学基金面上项目,主持miR-155调控Th1Th17细胞免疫应答在早期重症急性胰腺炎发病中的作用和机制,815705782016.01-2019.12

 

获得如下奖项:

1)上海第十人民医院第十届青年教师讲课比赛,一等奖(2011)

2)同济大学医学院青年教师讲课比赛,一等奖(2011)

3)同济大学医学院优秀PBL教案评比,一等奖(2011)

4)南京医科大学教学查房比赛,三等奖(2012;

5) 同济大学医学院优秀PBL教案评比, 二等奖(2014)

5)发明专利:一种新型的听诊器套装(实用新型,2010年);

6)省科技进步二等奖:IETM在非酒精性脂肪性肝病发生中的作用的研究(第二人);

7)参编:《江绍基胃肠病学》。

 

近三年发表文章(第一或通讯作者):

1)Tang MC. Cheng l. Zhao Y. Efficacy of Tiopronin in treatment of severe non-alcoholic fatty liver disease. European Review for Medical and Pharmacological Sciences. 2014 ,18(2):160-4 (通讯,IF:1.093)

2)Tang MC. Zhao Y. Identification of transcription factors and single nucleotide polymorphisms of Lrh1 and its homologous genes in Lrh1-knockout pancreas of mice. BMC Medical Genetics, 2014, 15:43.(通讯, SCI 2.536)

3)Jia RR. Zhao Y. Increased Interleukin-17/23 axis and C-reactive Protein Are Associated With Increased Disease Activity In Patients With Acute Pancreatitis. Pancreas, 2015,44(2):321-5.(通讯, SCI 3.008)

4)Qiu L. Zhao Y. Astragaloside IV ameliorates acute pancreatitis in rats by inhibiting the activation of nuclear factor-κB. International journal of molecular medicine, 2015,35:625-636 .(通讯, SCI 1.8)

5) Tang MC.  Zhao Y. Downregulation of CD9 promotes pancreatic cancer growth and metastasis through upregulation of epidermal growth factor on the cell surface. Oncol Rep, 2015,34(1):350-8 .(通讯, SCI 2.301)

6)Qiu L. Zhao Y. Comparison of Existing Clinical Scoring Systems in Predicting Severity and Prognoses of Hyperlipidemic Acute Pancreatitis in Chinese Patients: A Retrospective Study. Medicine (Baltimore). 2015 Jun;94(23):e957. doi: 10.1097/MD.0000000000000957.

.(通讯, SCI 5.8)

7)MaoC T.  Zhao Y. Lipoprotein lipase gene-deficient mice with hypertriglyceridaemia associated with acute pancreatitis. Acta Cir Bras. 2016 Oct;31(10):655-660. doi: 10.1590/S0102-865020160100000003.(通讯, SCI 0. 58)

8)Maochun Tang, Rongrong Jia, Shu Zhou, Hua Liu, Xiuying Ma, Yan Zhao. Overexpression of CO-029 in pancreatic ductal adenocarcinoma is associated with poor prognosis. Int J Clin Exp Med 2016;9(10):20158-20164.

9)Zhang T, Liu H, Wang D, Zong P, Guo C, Wang F, Wu D, Tang M, Zhou J, Zhao Y. Predicting the Severity of Acute Pancreatitis with Red Cell Distribution Width at Early Admission Stage. Shock. 2017 Sep 14. doi: 10.1097/SHK.0000000000000982. [Epub ahead of print]

10)Zhang T, Liu H, Wang D, Zong P, Guo C, Wang F, Wu D, Tang M, Zhou J, Zhao Y. Predicting the Severity of Acute Pancreatitis with Red Cell Distribution Width at Early Admission Stage. Shock. 2017 Sep 14. doi: 10.1097/SHK.0000000000000982. [Epub ahead of print]

11)Deqing Wu, Maochun Tang, Yan Zhao, Shu Zhou, Xiaorong Xu, MD, Feng Wang, Hua Liu, Meiqin Wu. Impact of Seasons and Festivals on the Onset of Acute Pancreatitis in Shanghai, China. Pancreas 2017 April, Num4, 496-503.

12)Tong Liu, Yan Zhao, Chuanyong Guo. The protective effects of shikonin on hepatic ischemia/reperfusion injury are mediated by the activation of the PI3K/Akt pathway. Scientific Reports.2017 Mar 7,44785.

13)邱雷,史建华,殷国建,胡国勇,王兴鹏,赵严. 黄芪甲苷对实验性大鼠重症急性胰腺炎的治疗作用. 上海医学. (03): 227-2302014.

14)赵严,汤茂春,孙瑞青,殷国健,王锋,胡国勇,王兴鹏. CD9蛋白在胰腺癌组织中的表达及其临床意义.中华消化杂志.34(7):21-23,2014.

15)张婷 赵严。 红细胞分布宽度在急性胰腺炎中的应用进展。中华胰腺病学,2017,17.170-72