瑞普逊研究院-科研团队
周建军 博士
个人简介:
2001年,毕业于北京大学生命科学学院,获得博士学位。2002年,赴美国德克萨斯州立大学安德森癌症中心进行博士后研究
研究方向:
长期专注于肿瘤干细胞的基础研究,尤其是实体肿瘤谱系和转移机制的探索。肿瘤干细胞在乳腺癌脑转移中的作用已经受到学者们关注,但确切具体分子机制尚不明确。近年来,研究团队对L1CAM这个粘附分子在三阴性乳腺癌细胞系靶向脑转移中的作用做了深入研究,发现L1CAM与定向脑转移相关,其表达谱特征与不同乳腺癌靶向转移克隆的特异性的高度相关。
代表性论文:
- Shan Wu#, Jianjun Zhou#, Jing Guo, Zhan Hua, Jianchen Li, Zai Wang. Apatinib inhibits tumor growth and angiogenesis in PNET models. Endocrine Connections. 2019 Jan 1;8(1):8-19. (共同第一)
- Jianjun Zhou, Lionel Feigenbaum, Carole Yee, Hongbin Song, and Clayton Yates. Mouse Prostate Epithelial Luminal Cells Lineage Originate in the Basal Layer Where the Primitive Stem/Early Progenitor Cells Reside: Implications for Identifying Prostate Cancer Stem Cells. BioMed Research International. 2013. doi:10.1155/2013/913179. Epub 2013 Jun 1.
- Jianjun Zhou, Honghe Wang, Virginetta Cannon, Karen Marie Wolcott, Hongbin Song, Clayton Yates. Side population rather than CD133+ cells distinguishes enriched tumorigenicity in hTERT immortalized primary prostate cancer cells. Molecular Cancer 2011 Sep 14;10:112. doi: 10.1186/1476-4598-10-112.
- Li, F., Glinskii, O.V., Zhou, J., Wilson, L.S., Barnes, S., Anthony, D.C., Glinsky, V.V. Identification and Analysis of Signaling Networks Potentially Involved in Breast Carcinoma Metastasis to the Brain. PLoS ONE. 2011, 6(7): e21977. doi:10.1371/journal.pone.0021977.
- Lubna Patrawala, Tammy Calhoun, Robin Schneider-Broussard, Jianjun Zhou, Kent Claypool and Dean G. Tang. Side population is enriched in tumorigenic, stem-like cancer cells, whereas ABCG2+ and ABCG2- cancer cells are similarly tumorigenic. Cancer Res. 2005 Jul 15;65(14):6207-19.