As of April 20, 2017, Cardiovascular disease and especially coronary artery disease, are the primary cause of morbidity and mortality worldwide. It is estimated that the annual number of human deaths related to the cardiovascular disease is over 17.5 million worldwide, of which 80% of these deaths are due to strokes and heart attacks and over 75% of these incidents occur in developing nations. A recent project, by the (WHO) World Health Organization, monitored coronary heart disease across 37 ethnic populations in over 20 countries from all four continents. The study lasted over ten years and clearly shows that the annual rate of heart-related/coronary events is 600/100,000 people. The most common issue was ventricular dysfunction followed by myocardial infarction or heart attacks. A diagnosis of MI means that a patient’s heart muscle rapidly lost its blood supply. Without immediate treatment of the blockage, the event will lead to permanent damage in the affected areas of the heart. Myocardial Infarction is also known as coronary thrombosis which is the medical term for heart attack. (Limsuwan et al. 2010)*

Stem Cell Treatment After Acute Myocardial Infarction

Cardiac tissue regeneration using cardiopoietic stem cells. Regenerate heart tissue and Arteriogenesis leads to improvement in overall cardiac function and reduction in the infarct zone without invasive surgery or adverse side effects.

What Causes Heart Attacks?

The most common causes MI (Myocardial Infarction) is thrombosis or blood clots. These clots usually form inside one of the branches of the coronary artery. The clot restricts vital blood flow to the heart. This type of blood clotting doesn’t usually appear in healthy arteries unless there are existing atheromas within the arterial lining. Atheromas or plaque are fatty patches that develop in the linings of blood arteries. These types of plaque formations usually form over several years and can manifest more than one place inside the coronary arteries. Each Atheromas consists of an outer shell and soft inner core.(Boonbaichaiyapruck et al. 2010)*

If a crack develops on the outer atheroma plaque shell, the event is known as a plaque rupture. This rupture exposes the inner core to circulating blood which triggers the blood clotting mechanism resulting in a blood clot. A build up of plaque is usually the underlying issue that leads to the death of heart muscle cells and a heart attack. It’s worth noting that atheromas can develop in any part of the coronary arteries. If caught early enough, anti-clogging medications can be used to safely break up the blood clot and eliminate the blockage before it too late.

Other causes of blocked arteries and Cardiac Infarctions include:

• Chronic inflammation of the coronary arteries

• Complications from open heart surgeries

• Direct impact with heart tissue, i.e., stab wounds

• A clot forming elsewhere then travels to coronary artery and causes blockage

• Drug abuse can also cause a coronary artery to go into spasm

• Failed surgeries leading to death of cardiac muscle

Symptoms of a Pending Heart Attack

                          Cardiac Cell in a Dish

The body displays several warnings leading up to a heart attack. The most common symptom is severe chest pain, but pain can also travel to the jaw area, along with the right or left arm (or both). Patients also report heavy sweating, feeling faint or sick. The pain experienced by patients is very similar to angina, but it’s usually much more severe and persists for longer. While angina pain usually disappears after a few minutes, Pain from a heart attack lasts anywhere from 10 minutes to several hours.(Srimahachota et al. 2011)*

A small/minor heart attack can occur without pain (‘Silent Myocardial Infarction’) or the pain relatively mild leading the victim to think it’s just lack of oxygen or heartburn. Significant or severe heart attacks can cause instant collapse and result in sudden death. If addressed early after the initial incident, a lot of people can recover without further complications.

For some patients, an emergency angioplasty is required as an alternative to a ‘clot-busting’ medications. An angioplasty procedure uses tiny wires with a balloon attached to the end. The wire is guided into the large artery in the patient’s arm or groin area. The wire then travels up to the heart and directly into any blocked coronary artery using with the assistance of radio guidance. When it reaches the area of blockage, the balloon is inflated, allowing the blocked artery widen and thus breaking up any plaque formations.(Hou et al. 2013)*

Stem Cells for Coronary Thrombosis & Acute Myocardial Infarctions

Cardiac Stem cell treatments (CSC’s) are the only safe and non-surgical method to improve ventricular muscle function after ischemic injury. Cardiac stem cell repair works by engrafting/delivering new cardiomyocytes, endothelial cells and cardiac pacemaker cells to the infarct zone (damaged area) which help to replace the (necrotic) dead myocardium tissue, induce arteriogenesis and help establish new blood microvessels through the process known as angiogenesis. The Regen Centre Stem Cell Treatment for Heart Attacks uses cultured and differentiated stem cells to restore cardiac function via remuscularization process. The enhanced hematopoietic stem cells used in treatments for Congestive Heart Failure and coronary heart disease yield significantly larger populations of cardiomyocytes allowing for better long-term cardiovascular health.

Long Term Results of MSC+ Cardiac Cell Therapy with Regen Center

The heart regeneration protocol for damaged myocardium treatment also focuses on the creation of both endothelial and vascular muscle cells that help increase blood supply needed for myocardial repair along with the paracrine effect. Cell development improves Paracrine signaling (cell-cell communication) which is critical in helping induce regenerative changes in surrounding cells and can be observed after cell infusions in (bFGF) fibroblast growth factors, (PDGF) platelet derived growth factors, interleukin-1b & TGF-b and play a vital immunomodulatory role in repairing heart tissue after heart attacks.(Carvalho et al. 2015)*

TREATMENT PRECAUTION

Please note Stem Cell Therapies may not be appropriate for all Heart Conditions. Cell Therapy and Heart tissue and cell Engineering are limited based on the extent of heart muscle and tissue damage and current and accurate medical condition of the patient. Travel Restrictions may apply. Patients requiring sustained oxygen assistance will not qualify for treatment.

Delivery of Stem Cells after Heart Attacks

Methods of delivery or adult cardiac myocytes to the damaged myocardium can be done in both surgical and noninvasive methods depending on the patient’s condition and needs. Minimally invasive means include catheter-based cell delivery, intracoronary transplantation, Intracoronary or trans-endocardial injection, however, carry much more risk resulting in the need for concomitant open heart surgery. Through proper cell culturing, Cell Isolation, G-CSF and cell differentiation techniques, non-invasive, non-surgical cell delivery can be achieved using then the combination of intravenous and intramuscular cell infusions needed to circumvent dead heart muscle.(Nartprayut et al. 2013)*

Treatment Overview


Number of Cell Infusions: 2-6 Clinical Grade Cell Cardiotopoietic Stem cells (per Treatment stage requirement) Severe cases with multiple commodities may require a multiple stage delivery using transvascular injections with direct injection Into the ventricular walls to ensure optimal results.

Physical Rehabilitation Post Therapy: Rehabilitation therapy is optional based on the patients time constraints. Full rehabilitation and nursing care can be provided 1-6 hours per day and up to 5 days per week
. Medical visas and accommodations for the patient and family/friends at an extended stay hotel can also be included upon request. Estimated treatment length is 14 – 21 nights in total.